23 January, 2006
Neurological disorders: Are they infections?
In one study, 90 percent of the brains of Alzheimer's victims contained the pneumonia bacteria, Chlamidia pneumoniae while only 5 percent of non-Alzheimer's brains contained the same bacteria. Read more at....
http://www.usnews.com/usnews/health/briefs/alzheimers_neurological/hb041102.htm
In the case of MS, there is evidence for an association of the disease with chronic bacterial and viral infections. Chmielewska-Badora et al. [10] found that 38.5% of MS patients showed evidence of Borrelia antigens in their blood, whereas other neurological patients carried these antigens in blood at a lower prevalence (19%). Chlamydia pneumoniae has also been found in a subgroup of MS patients [11]. By examining cerebral spinal fluid (CSF) these authors found that 10% of MS patients and 18% of patients with probable MS had Chlamydia infections but none of 56 control patients with other neurological disease were positive [11]. Read more at......
http://www.fibromyalgiasupport.com/library/showarticle.cfm/ID/4243/e/1/T/CFIDS_FM/
...evidence that the bacteria (C. pneumoniae) could be involved in the disease (MS) came from the Subramaniam Sriram’s team at the Vanderbilt University Multiple Sclerosis Center in Nashville, Tenn. He previously reported that 97 percent of MS patients had evidence of C. pneumoniae infection in the central nervous system, compared with only 16 percent in patients with other neurological diseases.
More importantly, Chlamydia antigens precipitated out of the oligoclonal bands. “That’s an amazing result – nobody had been able to do that before and the existence of these bands has been known about for more than 60 years,” Dr. Lenz said.
Now Dr. Lenz and his colleagues have taken the work a stage further. By searching through the chlamydial genome, they found a region coding for a protein fragment that closely resembled the MBP 68-86 region of the myelin protein known to be the main target in EAE. Both peptides were found to activate the T cells that stimulate the encephalitis response, and affected rats showed similar signs of disease. Read more at...
http://www.med.wayne.edu/Scribe/scribe01-02/winter02/a-bacterial%20genomics%20reveals%20ms%20trigger.htm
It has been noted that certain neurological diseases have accompanying gastrointestinal manifestations, particularly constipation and diarrhea. This suggests the possibility that an intestinal microorganism may be the cause of both aspects of the disease. In turn, this implies that appropriate antimicrobial therapy might lead to improvement in both gastrointestinal and the neurological aspects. This has been demonstrated in late onset autism (response has been demonstrated with the administration of oral vancomycin and metronidazole), and there are isolated anecdotal reports of improvement in patients with Alzheimer’s disease, schizophrenia, and Parkinson’s disease. Additional diseases that might have similar pathogenesis include attention deficit hyperactivity disorder (ADHD), depression, bipolar disorder, Whipple’s disease, Tourette’s syndrome, Asperger’s syndrome, and Rhett’s syndrome. Disrupted gut microbial flora can also lead to antimicrobial-associated diarrhea and play a role in irritable bowel syndrome and inflammatory bowel disease (ulcerative colitis and Crohn’s disease).
Read more at....
http://www.vard.org/tts/avail/00-075.htm
Could probiotic preparations containing immune-stimulating species such as L. acidophilus LAFTI strain L10 and B. lactis LAFTI strain B94, which also have the ability to suppress intestinal populations of pathogenic bacteria, be a useful adjunct in the treatment of neurological disorders?
In one study, 90 percent of the brains of Alzheimer's victims contained the pneumonia bacteria, Chlamidia pneumoniae while only 5 percent of non-Alzheimer's brains contained the same bacteria. Read more at....
http://www.usnews.com/usnews/health/briefs/alzheimers_neurological/hb041102.htm
In the case of MS, there is evidence for an association of the disease with chronic bacterial and viral infections. Chmielewska-Badora et al. [10] found that 38.5% of MS patients showed evidence of Borrelia antigens in their blood, whereas other neurological patients carried these antigens in blood at a lower prevalence (19%). Chlamydia pneumoniae has also been found in a subgroup of MS patients [11]. By examining cerebral spinal fluid (CSF) these authors found that 10% of MS patients and 18% of patients with probable MS had Chlamydia infections but none of 56 control patients with other neurological disease were positive [11]. Read more at......
http://www.fibromyalgiasupport.com/library/showarticle.cfm/ID/4243/e/1/T/CFIDS_FM/
...evidence that the bacteria (C. pneumoniae) could be involved in the disease (MS) came from the Subramaniam Sriram’s team at the Vanderbilt University Multiple Sclerosis Center in Nashville, Tenn. He previously reported that 97 percent of MS patients had evidence of C. pneumoniae infection in the central nervous system, compared with only 16 percent in patients with other neurological diseases.
More importantly, Chlamydia antigens precipitated out of the oligoclonal bands. “That’s an amazing result – nobody had been able to do that before and the existence of these bands has been known about for more than 60 years,” Dr. Lenz said.
Now Dr. Lenz and his colleagues have taken the work a stage further. By searching through the chlamydial genome, they found a region coding for a protein fragment that closely resembled the MBP 68-86 region of the myelin protein known to be the main target in EAE. Both peptides were found to activate the T cells that stimulate the encephalitis response, and affected rats showed similar signs of disease. Read more at...
http://www.med.wayne.edu/Scribe/scribe01-02/winter02/a-bacterial%20genomics%20reveals%20ms%20trigger.htm
It has been noted that certain neurological diseases have accompanying gastrointestinal manifestations, particularly constipation and diarrhea. This suggests the possibility that an intestinal microorganism may be the cause of both aspects of the disease. In turn, this implies that appropriate antimicrobial therapy might lead to improvement in both gastrointestinal and the neurological aspects. This has been demonstrated in late onset autism (response has been demonstrated with the administration of oral vancomycin and metronidazole), and there are isolated anecdotal reports of improvement in patients with Alzheimer’s disease, schizophrenia, and Parkinson’s disease. Additional diseases that might have similar pathogenesis include attention deficit hyperactivity disorder (ADHD), depression, bipolar disorder, Whipple’s disease, Tourette’s syndrome, Asperger’s syndrome, and Rhett’s syndrome. Disrupted gut microbial flora can also lead to antimicrobial-associated diarrhea and play a role in irritable bowel syndrome and inflammatory bowel disease (ulcerative colitis and Crohn’s disease).
Read more at....
http://www.vard.org/tts/avail/00-075.htm
Could probiotic preparations containing immune-stimulating species such as L. acidophilus LAFTI strain L10 and B. lactis LAFTI strain B94, which also have the ability to suppress intestinal populations of pathogenic bacteria, be a useful adjunct in the treatment of neurological disorders?
